Available for Android and iOS devices. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. It has not been shown to cause different side effects or problems than it does in adults. It is best to drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug in order to prevent kidney stones. Also, drinking too much alcohol may increase the amount of uric acid in the blood and lessen the effects of probenecid. Probenecid is available only with your doctor's prescription. Using probenecid with any of the following medicines is not recommended. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To prevent gout, take this medication by mouth, usually twice daily with food or antacids to reduce stomach upset or as directed by your doctor. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Generic Name: probenecid (proe BEN a sid)Brand Name: BenemidDosage Forms: oral tablet (500 mg). It is important that you follow your doctor's instructions very carefully. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. We comply with the HONcode standard for trustworthy health information -, Cancer being treated by antineoplastics (cancer medicine) or radiation (x-rays) or, Kidney disease or stones (or history of) or, Stomach ulcer (history of)—The chance of side effects may be increased. Probenecid colchicine (probenecid / colchicine) isn’t a first choice medicine to treat or prevent gout. Generic Name : Probenecid Pronunciation : proe ben' e sid Latest prescription information about Probenecid. Probenecid is a uricosuric and renal tubular transport blocking agent. Written by Cerner Multum. Probenecid belongs to a class of drugs known as uricosurics. Click again to see term . It acts on the kidneys to help the body eliminate uric acid. Medically reviewed by Drugs.com. Last updated on Nov 20, 2020. prednisone, allopurinol, triamcinolone, dexamethasone, betamethasone, Decadron, febuxostat, Uloric, Zyloprim, allopurinol / lesinurad. Do not double doses. Other times, the dose will be 1 tablet four times a day. Probenecid (former brand name Benemid) is a drug prescribed for the treatment of gout and kidney stones. It is also used to increase the effectiveness of some antibiotics. These medications are not usually taken together. Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. Probenecid has been tested in children 2 to 14 years of age for use together with antibiotics. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. For patients taking probenecid for gout or to help remove uric acid from the body: The dose of probenecid will be different for different patients. Taking aspirin or other salicylates may lessen the effects of probenecid. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. Medscape - Gout dosing for colchicine/probenecid, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Access … Pregnancy risk category B Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The following information includes only the average doses of probenecid. Uricosric antigout agent. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Visit cvs.com for more details. Probenecid systemic 500 mg (MYLAN 156 500). Tap again to see term . Disclaimer: This information is independently developed by CIMS based on probenecid from various references and is provided for your reference only. Call your doctor for medical advice about side effects. puffiness or swellings of the eyelids or around the eyes, shortness of breath, troubled breathing, tightness in chest, or wheezing, changes in the skin color of the face occurring together with any of the other side effects listed here, or skin rash, hives, or itching occurring together with any of the other side effects listed here, lower back or side pain (especially if severe or sharp), skin rash, hives, or itching (occurring without other signs of an allergic reaction), sores, ulcers, or white spots on lips or in mouth, sore throat and fever with or without chills, swelling of face, fingers, feet, and/or lower legs, flushing or redness of face (occurring without any signs of an allergic reaction). Probenecid is used to treat gout and gouty arthritis. If stomach upset (nausea, vomiting, or loss of appetite) continues, check with your doctor. These conditions are caused by too much uric acid in the blood. Probenecid is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Gout is very rare in children. 10903 New Hampshire Avenue Silver Spring, MD 20993 Ph. Most cephalosporins are affected to some degree by concurrent probenecid administration, although ceforanide, ceftazidime, ceftriaxone and latamoxef (moxalactam) have no significant changes in pharmacokinetics. Follow your doctor's orders or the directions on the label. Not all possible drug interactions are listed here. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Version: 4.03. prednisone, allopurinol, triamcinolone, dexamethasone, betamethasone, Decadron, febuxostat, Uloric, Zyloprim, allopurinol / lesinurad. This is a decision you and your doctor will make. Compare formulary status to other drugs in the same class. Available for Android and iOS devices. Other drugs may affect probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Many medicines have not been studied specifically in older people. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Probenecid Drug Class. Does PROBENECID Interact with other Medications? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Probenecid is also sometimes given together with penicillin antibiotics (including ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin) to make them more effective. Before you have any medical tests, tell the person in charge that you are taking probenecid. Drug class(es): antigout agents Probenecid systemic is used in the treatment of: Adjunct to Antibiotic Therapy; Gout; Gouty Arthritis; Multi-ingredient medications containing probenecid: ampicillin/probenecid systemic. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using probenecid with any of the following medicines is usually not recommended, but may be required in some cases. Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. Avoid using any medicine that may contain aspirin or other salicylates (such as Disalsid, Doan's Extra Strength, Ecotrin, Novasal, Nuprin Backache, Salflex, Salsitab, Tricosal, Trilisate, and others). Tell your doctor if you are pregnant or breast-feeding. Studies on the effects of probenecid in patients with gout have been done only in adults. Drug class: Xanthine Oxidase Inhibitors Allopurinol (Zyloprim) is a moderately priced drug used to treat the symptoms of gout . However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. The amount of medicine that you take depends on the strength of the medicine. Sometimes, only one dose of 2 tablets is needed. Do not keep outdated medicine or medicine no longer needed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Probenecid is a prescription medication used to treat high uric acid levels associated with gout and gouty arthritis. However, if you take probenecid regularly as directed by your doctor, the attacks will gradually become less frequent and less painful than before. If a child needs probenecid, however, the dose would have to be determined by the doctor. The effect of concurrent probenecid administration on the pharmacokinetics of cephalosporin antibiotics varies with the available cephalosporins. Uses of Probenecid-hyperurrcemia in gout-gouty arthritis flushing (sudden warmth, redness, or tingly feeling); This is not a complete list of side effects and others may occur. Probenecid should not be given to a child younger than 2 years old. Probenceid chemistry name. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Each tablet for oral administration contains 500 mg of Probenecid and the following inactive ingredients: Microcrystalline ce… Click card to see definition . Your doctor may also instruct you on how to decrease acidity in your urine (e.g., avoid large amounts of ascorbic acid/vitamin C) to pr… Your doctor may also instruct you on how to decreas… Although not all of these side effects may occur, if they do occur they may need medical attention. These conditions are caused by too much uric acid in the blood. Use the medicine exactly as directed. It depends on the child's weight, as well as on the condition being treated. You may be given other medications to also help prevent kidney stones. The medicine works by removing the extra uric acid from the body. 43 In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. It is best to drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug in order to prevent kidney stones. Therapeutic class: Antigout drug, tubular blocking agent. Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. When you first begin taking probenecid, the amount of uric acid in the kidneys is greatly increased. Probenecid belongs to a class of drugs known as uricosurics. If you are on restricted fluid intake, consult your doctor for further instructions. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Gravity. For treating gout or removing uric acid from the body: Adults: 250 mg (one-half of a 500-mg tablet) two times a day for about one week, then 500 mg (one tablet) two times a day for a few weeks. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. 43 Peak concentrations are reached in 1 to 5 hours, and the peak action occurs about 2 hours after an oral dose with effects lasting up to 8 hours. It has the following structural formula: Probenecid, USP is a white or nearly white, fine, crystalline powder. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Probenecid is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids. Store at room temperature away from moisture, heat, and light. Even if you take another medicine for gout attacks, continue to take probenecid also. 1-888-INFO-FDA (1-888-463-6332) Contact FDA Adults: The amount of probenecid will depend on the condition being treated. There is no specific information comparing use of probenecid in the elderly with use in other age groups. Children: The dose will have to be determined by the doctor. The presence of other medical problems may affect the use of probenecid. Drug Interactions: When probenecid is used to elevate plasma concentrations of penicillin or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. If you have any questions about this, check with your doctor. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Used in the treatment of gout. If you need surgery, tell your surgeon you currently take probenecid. It is also used to treat or prevent high uric acid levels that occur as a result of certain types of chemotherapy. Select one or more newsletters to continue. Beta-lactam antibiotics. Probenecid may cause false test results with copper sulfate urine sugar tests (Clinitest®), but not with glucose enzymatic urine sugar tests (Clinistix®). Probenecid is also sometimes given together with penicillin antibiotics (including ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin) to make them more effective. Affected cytochrome P450 isoenzymes and drug transporters: OAT1 and OAT3 Probenecid inhibits the drug transporters OAT1 and OAT3. Copyright 1996-2021 Cerner Multum, Inc. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. SW Probenecid(probenecid): ... Drug Interactions . Keep using these medicines for as long as your doctor has prescribed. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. NCI Thesaurus (NCIt) Probenecid is a uricosuric agent used for the treatment of gout usually in combination with other agents. After you begin to take probenecid, gout attacks may continue to occur for a while. Used in the treatment of gout. Probenecid will help prevent gout attacks only as long as you continue to take it. Probenecid Drug Class : Uric acid (Uricosuric) Brand Names : Generic only Used in the treatment of gout., Uricosric antigout agent. Drink plenty of water to prevent kidney stones while you are taking probenecid. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Action of Probenceid-inhibits tubular reabsorption of urates which increase execration of uric acid. Probenecid is a uricosuric and renal tubular blocking agent and is used in combination … When uric acid levels get too high, crystals can form in the joints, causing gout. Psychic disturbances w/ penicillin or other β-lactams. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Do not take two doses at one time. sulfonamide derrivitive. When you are taking probenecid, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Probenecid is used in the treatment of chronic gout or gouty arthritis. These side effects may go away during treatment as your body adjusts to the medicine. You may report side effects to FDA at 1-800-FDA-1088. Using probenecid with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Probenecid may also be used for purposes not listed in this medication guide. Medically reviewed by Drugs.com on Dec 9, 2020. Follow all directions on your prescription label and read all medication guides or instruction sheets. Match. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. It is primarily used in treating gout and hyperuricemia. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Using alcohol or tobacco with certain medicines may also cause interactions to occur. For non-prescription products, read the label or package ingredients carefully. [56579] Probenecid inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. Probenecid is used to treat chronic gout and gouty arthritis. Ask a doctor or pharmacist if you feel you need to take a mild pain reliever. Most people need 2, 3, or 4 tablets a day, but some people may need higher doses. Brand names: Probenecid and Colchicine, Proben-C Drug class(es): antigout agents If your dose is different, do not change it unless your doctor tells you to do so. Probenecid will help prevent gout attacks but it will not relieve an attack that has already started. Probenecid is used to treat gout and gouty arthritis. If you miss a dose of probenecid, take it as soon as possible. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine. Children: It is not likely that probenecid will be needed to treat gout or to remove uric acid from the body in children. Generic Name: probenecid (proe-BEN-e-sid). Probenecid is also used to make certain antibiotics more effective by preventing the body from passing them in the urine. If this does not work, an antacid may be taken. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Along with its needed effects, a medicine may cause some unwanted effects. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. Probenecid is well absorbed when given orally and provides drug levels equivalent to the IV form, no longer available in the United States. Older children and teenagers may need the same amount as adults. Probenecid is used in the treatment of chronic gout or gouty arthritis. After this, the dose will depend on the amount of uric acid in your blood or urine. Tell your doctor about all your other medicines, especially: an NSAID (nonsteroidal anti-inflammatory drug) such as indomethacin, ketoprofen, meclofenamate, or naproxen (Aleve). Tap card to see definition . For probenecid, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to probenecid or any other medicines. Review side effects, dosage, warnings and precautions, and drug interactions prior to taking this medication. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Call your doctor for medical advice about side effects. Your doctor may prescribe an additional medicine called colchicine. This list is not complete. Pharmacologic class: Sulfonamide-derived uricosuric. After you have been taking probenecid for several months, they may stop completely. Make sure you tell your doctor if you have any other medical problems, especially: If probenecid upsets your stomach, it may be taken with food. Probenecid is also used to prevent or treat other medical problems that may occur if too much uric acid is present in t… colchicine/probenecid systemic. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. Call your doctor if you have worsening gout symptoms. Overdose symptoms may include nausea, vomiting, or stomach discomfort. If you notice any other effects, check with your healthcare professional. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. probenecid may affect your body's response to anesthesia. The chemical name for Probenecid is 4-[(dipropylamino) sulfony1] benzoic acid. Check with your doctor immediately if any of the following side effects occur: Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. nausea, vomiting, stomach pain or swelling; puffy eyes, swelling in your ankles or feet, weight gain; or. If you have any questions about this, check with your health care professional. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drug class(es): aminopenicillins. Probenecid has been used in patients with some renal impairment, but dosage requirements may be increased; probenecid may not be effective in chronic renal insufficiency particularly when the glomerular filtration rate is ≤30 mL/minute because of its mechanism of action, probenecid is not recommended in conjunction with penicillin in the presence of known renal impairment Probenecid is also used to prevent or treat other medical problems that may occur if too much uric acid is present in the body. 43 Probenecid is extensively protein bound, ranging from 83% to 95% depending on the dose. Probenceid chemistry name. The medicine works by removing the extra uric acid from the body. This may cause kidney stones or other kidney problems in some people. You may report side effects to the FDA at 1-800-FDA-1088. Probenecid will help prevent gout attacks only as long as you continue to take it. Probenecid Drug Class. If you are on restricted fluid intake, consult your doctor for further instructions. Therefore, do not take aspirin or other salicylates or drink alcoholic beverages while taking probenecid, unless you have first checked with your doctor. Probenecid is also used to increase the blood levels of penicillin-type antibiotics used for the treatment of gonorrhea. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. M04AB01 - probenecid ; Belongs to the class of preparations increasing uric acid excretion. Find everything you need to know about Probenecid (Benemid), including what it is used for, warnings, reviews, side effects, and interactions. It is used to prevent attacks related to gout, not treat them once they occur. a blood cell disorder, such as anemia or low white blood cells. Probenecid colchicine (probenecid / colchicine) can be used to stop gout attacks but you shouldn't start it until after the gout attack is over. You should not use this medicine if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder. If you will be taking probenecid for more than a few weeks, your doctor should check your progress at regular visits. Probenecid belongs to a class of drugs known as uricosurics. probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine. Probenecid Oral tablet drug summary. You should not use probenecid if you are allergic to it, or if you have: a gout attack that has already started; or. Probenecid belongs to a group of drugs called renal tubular blocking agents. Probenecid systemic 500 mg (MYLAN 156 500), We comply with the HONcode standard for trustworthy health information -. Probenecid: Belongs to the class of preparations increasing uric acid excretion. Severe Interactions . Antagonized uricosuric ... M04AB01 - probenecid ; Belongs to the class of preparations increasing uric acid excretion. Call your doctor if your gout symptoms do not improve, or if they get worse. Keep from freezing. To prevent gout, take this medication by mouth, usually twice daily with food or antacids to reduce stomach upset or as directed by your doctor. Drug Review Package. The results of some tests may be affected by probenecid.

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